Oxorhenium(V) and Oxotechnetium(V) Complexes of N3S Tetradentate Ligands with a Styrylpyridyl Functional Group: Toward Imaging Agents to Assist in the Diagnosis of Alzheimer's Disease

B Spyrou; IN Hungnes; F Mota; J Bordoloi; PJ Blower; JM White; MT Ma; PS Donnelly

Journal article

Oxorhenium(V) and Oxotechnetium(V) Complexes of N3S Tetradentate Ligands with a Styrylpyridyl Functional Group: Toward Imaging Agents to Assist in the Diagnosis of Alzheimer's Disease

B Spyrou, IN Hungnes, F Mota, J Bordoloi, PJ Blower, JM White, MT Ma, PS Donnelly

Inorganic Chemistry | AMER CHEMICAL SOC | Published : 2021

DOI: 10.1021/acs.inorgchem.1c01992

Abstract

Alzheimer's disease (AD) is associated with the presence of amyloid plaques in the brain mainly comprised of aggregated forms of amyloid-β (Aβ). Molecules radiolabeled with technetium-99m that cross the blood-brain barrier (BBB) and selectively bind to Aβ plaques have the potential to assist in the diagnosis of AD using single-photon emission computed tomography imaging. In this work, three new tetradentate ligands of pyridyl, amide, amine and thiol donors, featuring a styrylpyridyl group that is known to interact with amyloid plaques, were prepared. The new ligands formed charge-neutral and lipophilic complexes with the [Tc═O]3+ and [Re═O]3+ motifs, and two rhenium complexes were characteri..

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University of Melbourne Researchers

Jonathan White Author

Paul Donnelly Author

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Grants

Awarded by Engineering and Physical Sciences Research Council

Funding Acknowledgements

Research funding was provided from the Australian Research Council (Grants LP150100656 and DP160100288 to P.S.D.). The Mass Spectrometry and Proteomics Facility at the Bio21 Institute, University of Melbourne, is thanked for use of their mass spectrometer and high-performance liquid chromatograph. This research was also supported by a Cancer Research UK Career Establishment Award (C63178/A24959), the EPSRC programme for Next Generation Molecular Imaging and Therapy with Radionuclides (EP/S032789/1, "MITH-RAS"), Rosetrees Trust (M685), and the Centre for Medical Engineering funded by the Wellcome Trust and the Engineering and Physical Sciences Research Council (WT088641/Z/09/Z).